• br Introduction Given the growing acceptance of ergothionein

  2022-05-19

  

  Introduction Given the growing acceptance of ergothioneine (ET) as a biologically important agent with potential therapeutic applications [[1], [2], [3], [4]] it is increasingly important to clearly establish the role of the organic cation transporter (novel) type 1 (OCTN1). OCTN1 was discovered

• Ajzenman et al reported improved

  2022-05-19

  

  Ajzenman et al reported improved stability and postural parameters in ASD children after EAT. Other authors presented similar findings,61, 62, 63, 64 although the studies were conducted among children with CP, and reported improved muscle symmetry,, stability of the head and the trunk, motor functio

• br Materials and methods br Results br

  2022-05-19

  

  Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the 2'-O-Methyl-ATP receptor of neu

• br Acknowledgments This work was supported by

  2022-05-19

  

  Acknowledgments This work was supported by a grant CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China (Grant Number 81061120525) and the Canadian Institutes for Health Research (Grant number CCI-109605). The authors thank two anonymous reviewers for helpful

• C steroids and their glycosylation

  2022-05-19

  

  C21 steroids and their glycosylation products distribute widely in Asclepiadaceae plants. Their anticancer activities have been shown in different human cell lines and in vivo animal experiments [[27], [28], [29], [30], [31], [32]]. However, the mechanisms of their anticancer activities are still un

• The eradication of agonist activity in compound

  2022-05-19

  

  The eradication of agonist activity in compound was also confirmed in the ex vivo growth hormone (GH) release experiment conducted in isolated primary rat pituitary tgf beta receptor as shown in . Compound did not produce any noticeable GH secretion at up to 10μM concentration. It could also anta

• For functional metagenomics based gene screening the DNA lib

  2022-05-19

  

  For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a

• SGI-1027 mg br Author contributions br Conflict

  2022-05-19

  

  Author contributions Conflict of interests Acknowledgements This work was supported by NIH grant DK098730 to NHM. Free fatty acids play important roles in biological processes contributing to both health and disease. As essential nutritional components, free fatty acids are utilized as b

• On the contrary the benzhydrol series showed modest

  2022-05-19

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the 92 8 tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to the unsubstitute

• br Declarations of interest br Founding information This wor

  2022-05-19

  

  Declarations of interest Founding information This work was partially supported by the New Energy and Industrial Technology Development Organization (NEDO) Japan [grant number P03043]; and Grants-in-Aid for Scientific Research [grant number 16H00738 to H.M.] from the Japan Society for the Prom

• Last we demonstrate that the role of EZH

  2022-05-19

  

  Last, we demonstrate that the role of EZH2 as a transcriptional activator, with AR being a key target, coexists with its conventional catalytic role in gene repression and plays important oncogenic functions in AR-driven PCa (Figure 7F). Enzymatic EZH2 inhibitors such as EPZ and GSK126, although eff

• br Methods The study was a cross sectional ecological analys

  2022-05-19

  

  Methods The study was a cross-sectional, ecological analysis of country-reported HIV expenditures. We obtained the most recent available and validated data on annual country-reported HIV expenditures in SSA countries between 2012 and 2017 from the UNAIDS (http://aidsinfo.unaids.org/). Many countr

• br Introduction Stroke is the second cause

  2022-05-19

  

  Introduction Stroke is the second cause of death worldwide and the first cause of acquired motor disability in adults [1], [2]. In sub-Saharan Africa, stroke is the first cause of admission in neurology departments [3]. In Cameroon, the in-hospital mortality of stroke is estimated at 26.8% [4]. A

• br Introduction Glycolysis plays a key role

  2022-05-19

  

  Introduction Glycolysis plays a key role in 11302 energy metabolism [[1], [2], [3]]. It is initiated mainly by hexokinase I (HKI), the major hexokinase isoform of the brain ([3,4] and references therein). Up to 90% of brain HKI is bound to the mitochondrial outer membrane (MOM) through the volta

• br Methods br Results br Discussion TA TMA

  2022-05-19

  

  Methods Results Discussion TA-TMA is a severe complication for patients after HSCT. The pathogenesis of TA-TMA is unclear. Complement activation and endothelial cell injury may be involved in the pathogenesis of TA-TMA. Our previous investigations had demonstrated that plasma levels of C5b-

15000 records 470/1000 page Previous Next First page 上5页 466467468469470 下5页 Last page