• br Introduction Glucagon is a peptide hormone that acts

  2021-11-29

  

  Introduction Glucagon is a peptide hormone that acts to increase blood glucose levels. The secretion of glucagon from the alpha BKM120 of the islets of Langerhans in the pancreas is increased during fasting and prevents hypoglycemia. Glucagon increases glycogenolysis and gluconeogenesis and ther

• Thus this work aims to evaluate the effect

  2021-11-29

  

  Thus, this work aims to evaluate the effect of tannic NSC 87877 on β-galactosidase activity, by observing the variations in the molecular interaction kinetic parameters ( and ). Besides, these data were correlated with the modifications that the tannin caused to the enzyme’s secondary structure (CD)

• br Introduction Farnesoid X receptor

  2021-11-29

  

  Introduction Farnesoid X receptor (FXR) is a bile 57 9 synthesis regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα) tha

• The present study also demonstrated that edoxaban inhibited

  2021-11-29

  

  The present study also demonstrated that edoxaban inhibited both free and clot-bound FXa activity. The IC50 values for free and clot-bound FXa in this study are well consistent with Ki values for free FXa and FXa incorporated in prothrombinase complex (0.561 and 2.98nM, respectively) in our previous

• Although it is well documented

  2021-11-29

  

  Although it is well documented that FAAH substrates can elicit analgesic effects [for review see [47,48] and that systemic poly I:C administration induces mechanical allodynia in rats [14], to our knowledge this is the first study to demonstrate that enhancing FAAH substrate levels can modulate TLR3

• In human cancers it has been

  2021-11-29

  

  In human cancers, it has been identified that FOXC2-AS1 functions as an oncogenic RNA. For instance, in osteosarcoma, FOXC2-AS1 regulates the expression of FOXC2 at the transcription and post-transcription levels to promote doxorubicin resistance by facilitating ABCB1 expression (C.L. Zhang et al.,

• Traditional methods for HATs activity assays mainly depend

  2021-11-29

  

  Traditional methods for HATs activity assays mainly depend on radioisotope labelling of histone substrates, which is limited by the complex procedures, hazards and wastes of radioactive materials. Hence, various alternative approaches such as electrochemical analysis, fluorescence and colorimetric a

• To date several studies have suggested that

  2021-11-29

  

  To date, several studies have suggested that serum HER2 could be used as a biomarker for monitoring the disease course and the patient's response to therapy [110], [111]. However, the clinical usefulness of serum HER2 has not been fully validated because of conflicting data [31]. The enzyme-linked i

• br Mechanisms of HDAC inhibition dependent cardioprotection

  2021-11-29

  

  Mechanisms of HDAC inhibition-dependent cardioprotection Multiple preclinical studies have demonstrated potent cardioprotective benefits of HDAC inhibition in murine models of myocardial stress, including I/R [19,25,29,30]. TSA reduces myocardial infarct size by up to 50% [19,25]. In addition, tr

• The general synthetic routes leading to aspartate and

  2021-11-29

  

  The general synthetic routes, leading to aspartate and 2,3-diaminopropionate analogs, are shown in . As outlined in , aspartic Gastrodin analogs – were synthesized through standard carbodiimide-mediated coupling between an amine and an appropriately protected aspartic acid. It is worth mentioning th

• br Introduction Major depressive disorder

  2021-11-26

  

  Introduction Major depressive disorder (MDD) is a disease with poorly recognized etiology. Currently used antidepressant drugs, which mainly affect synaptic neurotransmitter levels, show full clinical efficacy in only one third of patients (Rush, 2007). Thus it is now generally accepted that the

• 15 receptor Similar to C lividipennis RDL Jiang et al we

  2021-11-26

  

  Similar to C. lividipennis RDL (Jiang et al., 2015), we found that the intracellular loop variants of A. mellifera RDL had no effect on GABA EC50 (Table 1). Also, as with C. lividipennis, there was no significant difference in maximal GABA responses (Table 1). However, whereas the 31 amino acid inse

• In the present study the relative mRNA

  2021-11-26

  

  In the present study, the relative mRNA enkephalin levels of CsLCCH3 and Cs8916 subunits in the egg were the highest, which were consistent with those of LsLCCH3 and Ls8916 from L. striatellus (Wei et al., 2017b) and were also similar to CsRDLs (Sheng et al., 2018; Meng et al., 2018). Overall, the

• We found that silymarin induced more improvement of renal

  2021-11-26

  

  We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S

• The investigation in vitro revealed that aldolase as well

  2021-11-26

  

  The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po

14918 records 559/995 page Previous Next First page 上5页 556557558559560 下5页 Last page