• EAAT glutamate uptake is driven by the co transport

  2021-10-15

  

  EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit Propidium iodide of glutamate into the cell against a steep concentration gradient. A

• Taking into account abovementioned vitamin D deficiency

  2021-10-15

  

  Taking into account abovementioned, vitamin D3 deficiency effects on synaptic neurotransmission can be considered as targeting both Ca2+-independent and Ca2+-dependent processes. Ca2+-independent action of vitamin D3 deficiency is associated with a decrease in the expression of glutamate and GABA tr

• AKR D is very highly expressed in

  2021-10-15

  

  AKR1D1 is very highly expressed in human liver and based upon the observations outlined above, with respect to other steroid hormone pre-receptor metabolising enzymes, it is entirely plausible that AKR1D1 could represent a critical regulatory step in the control of metabolic phenotype within the liv

• Here we used chemogenetic modulation of MBH GHSR neurons

  2021-10-15

  

  Here, we used chemogenetic modulation of MBH GHSR neurons to address the role of the endogenous ghrelin system in the normal, hyperphagic response to a short-term fast. Studies demonstrating the requirement of an intact ghrelin-GHSR system for the rebound food intake following fasting have been inco

• Liver is the house for a variety of

  2021-10-14

  

  Liver is the house for a variety of xenobiotic-metabolizing dichloroacetate that produce reactive oxygen species as well as reactive metabolites (Johansson et al., 2009; Noh et al., 2017; Puntarulo and Cederbaum, 1998). When the enzymes act upon pre- or pro-haptens, the chemicals would be activated

• A common feature of ferroptosis

  2021-10-14

  

  A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty CPI-455 phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in PUFA f

• It is an exciting time

  2021-10-14

  

  It is an exciting time for translational histamine research, since preclinical studies show potential value for histamine receptor ligands. As reviewed above, there are several concerns for future studies of histamine and its role in the CNS. 1) Because of the availability of HDC-Cre mice (Williams

• br Introduction Circulating tumor cells CTCs are cancer cell

  2021-10-14

  

  Introduction Circulating tumor Annexin V-Cy5 Apoptosis Kit (CTCs) are cancer cells that have invaded blood vessels or lymphatics and are carried around the body by the blood. CTCs constitute potential seeds for metastasis because they can reach and implant into distant organs. The clinical impo

• The endocytic inhibitors MDC and CPZ and

  2021-10-14

  

  The endocytic inhibitors MDC and CPZ and dynamin GTPase blocker (dynamin mutant) have been shown to significantly decrease the intracellular accumulation of cGMP. Moreover, earlier reports suggested that G-protein-coupled receptor (GPCRs) continue to signal by generating cAMP throughout internalizat

• We have previously established the pharmacokinetic

  2021-10-14

  

  We have previously established the pharmacokinetic profile and effective dose of MNF in the rat [43] and demonstrated the effectiveness of MNF as an anticancer drug in adenosine receptor agonist and xenograft models [44]. Moreover, MNF was found to effectively block GPR55 signaling in tumor cells [2

• The first hypothesis better fertility in heifers that

  2021-10-14

  

  The first hypothesis, better fertility in heifers that had CL at day 0, was clearly supported by our results. Heifers with a CL had over 60% P/AI compared to ∼50% in heifers without CL. These results are consistent with several other studies reporting that cycling heifers have greater fertility than

• After brain injury adenosine levels

  2021-10-14

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

• br Material and methods br Results br

  2021-10-14

  

  Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a

• Type diabetes mellitus is characterised by two major

  2021-10-14

  

  Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta ruthenium red australia [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due to insulin res

• br Do the actions of GLP R

  2021-10-14

  

  Do the actions of GLP-1R agonists on the vascular endothelium account for GLP-1R agonist-mediated cardioprotection? The previous section highlighted the recent clinical evidence from cardiovascular outcomes studies supporting the notion that GLP-1R agonists confer cardioprotective actions in pati

14868 records 584/992 page Previous Next First page 上5页 581582583584585 下5页 Last page