• These preliminary results prompted the

  2020-08-05

  

  These preliminary results prompted the establishment of a rapid developmental program (Table 2) and granted, in May 2014, the U.S. FDA Breakthrough Therapy designation for the treatment of mutant NSCLCs with the T790M 2-D08 after progression on EGFR-directed therapy. Unfortunately, on May 2016 Clo

• Proinflammatory cytokines induce ER stress in many mammalian

  2020-08-05

  

  Proinflammatory cytokines induce ER stress in many mammalian cell systems.32, 33, 34 Our results demonstrate that these cytokines also trigger ER stress in trophoblast JEG-3 cells. However, the severity of stress is likely low grade because only the PERK-EIF2A arm of the UPRER pathway was activated.

• br Drug Target Potential TM receptors and in particular clas

  2020-08-05

  

  Drug-Target Potential 7TM receptors and in particular class A receptors to which the 7TM receptors mentioned in this review belong, are highly druggable molecules. Approximately, 35% of all currently marketed drugs target class A 7TM receptors. There is no specific antiviral treatment for EBV. Cu

• In the present study we investigated the role of

  2020-08-05

  

  In the present study, we investigated the role of Ch25h and its downstream oxysterols during EAE. We demonstrated that Ch25h deletion attenuates EAE development by controlling the trafficking of encephalitogenic CD4+ T cell subsets. We further described molecular mechanisms allowing specific oxyster

• Cardiac remodeling after MI is caused

  2020-08-05

  

  Cardiac remodeling after MI is caused by activated myofibroblasts. They are attracted to the infarct region by various chemotactic factors, including TGF-β1, which is mainly produced by fibroblasts. TGF-β1 promotes trans-differentiation from fibroblasts to myofibroblasts, and upregulates biosynthesi

• Substituents at the C position An oxygen containing

  2020-08-05

  

  Substituents at the C11 position — An oxygen-containing substituent at the C11 position also affects the catalytic activity of Δ1-KSTDs. The Δ1-KSTDs from the Gram-positive bacteria R. equi [29], N. simplex ATCC 6946 and IFO 12069 [48,49,52], and R. rhodochrous IFO 3338 [27] were able to 1(2)-dehydr

• br Epilepsy and treatment Refractory epilepsy severely

  2020-08-05

  

  Epilepsy and treatment Refractory epilepsy severely impacts quality of life and neurodevelopment.14, 34 Median age of epilepsy onset is six weeks with 90% onset by three months.13, 14 Eighty percent of children with CDD have daily seizures and 20% have weekly to monthly seizures. Less than half (

• br Strategies for producing long acting protein therapeutics

  2020-08-05

  

  Strategies for producing long-acting protein therapeutics Significant effort has been expended to discover different approaches to extend the half-lives of protein drugs, not least by evading or interfering with their common clearance pathway. Modifications to protein drugs that prolong their hal

• CRM is the most prominent nuclear export receptor

  2020-08-04

  

  CRM1 is the most-prominent nuclear export receptor (Fornerod et al., 1997a, Fukuda et al., 1997, Kehlenbach et al., 1998, Ossareh-Nazari et al., 1997). It transports hundreds of different Levofloxacin harboring nuclear export signals (NESs) out of the nucleus and is also a major factor in RNA expor

• On the basis of the findings described

  2020-08-04

  

  On the basis of the findings described above, a series of heterotricyclic analogs were designed and synthesized. The human CRF1 receptor binding and antagonist activity data for newly designed heterotricyclic core antagonists 28–33 are described in Table 3. Most of the tricyclic core analogs listed

• br Theoretical and Empirical Limits of Substrate Specificity

  2020-08-04

  

  Theoretical and Empirical Limits of Substrate Specificity That substrate specificity is inherently limited was first glimpsed by Pauling 60 years ago [15] in relation to the process of aminoacyl-tRNA synthesis. He focused in particular on the case of isoleucyl-tRNA synthetase that must distinguis

• br Theoretical and Empirical Limits of Substrate Specificity

  2020-08-04

  

  Theoretical and Empirical Limits of Substrate Specificity That substrate specificity is inherently limited was first glimpsed by Pauling 60 years ago [15] in relation to the process of aminoacyl-tRNA synthesis. He focused in particular on the case of isoleucyl-tRNA synthetase that must distinguis

• br Materials and methods br Results Assay of botulinum toxin

  2020-08-04

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patien

• Although CYP E is also suspected of

  2020-08-04

  

  Although CYP2E1 is also suspected of being the major catalyst of CCl4 reduction in humans [7], the role of the various human CYP450 forms in CCl4 metabolism over a range of CCl4 concentrations has not been established. An understanding of which CYP450 forms contribute to CCl4 metabolism would provid

• br Disclosure conflict of interest br

  2020-08-04

  

  Disclosure/conflict of interest Acknowledgments Introduction Results Discussion Oxysterols and EBI2 have received growing attention in the field of immunology, with works highlighting an important role for EBI2 in immune cell migration. However, these studies are mainly limited to ani

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