• br Conclusion br Acknowledgements br Introduction

  2020-06-19

  

  Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super

• Meanwhile high levels of extraversion have been associated w

  2020-06-19

  

  Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster Wortmannin learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al., 2005) with sever

• Although the presence of at least one triple

  2020-06-19

  

  Although the presence of at least one triple helix domain is typically the collagen signature, collagens are modular proteins composed of a succession of collagenous (COL) and non-collagenous domains (NC) that are both involved in collagen functions and in receptor binding. COL domains are linked by

• phalloidin br Conclusion This patient was hypercoaguable

  2020-06-19

  

  Conclusion This patient was hypercoaguable as evidenced by a lower extremity DVT, pulmonary emboli, and a splenic infarct. Excluding acute CMV infectious mononucleosis, she had no disorders predisposing to splenic infarcts.4, 5 In this case, CMV infectious mononucleosis was accompanied by CMV lun

• Mitochondrial depolarization induced by DHODH inhibition Fig

  2020-06-18

  

  Mitochondrial depolarization induced by DHODH inhibition (Figure 5A) may also contribute to the selective effects of DHODH inhibitors on KRAS mutant cells. If so, the effect may arise more from pro-apoptotic effects of mitochondrial depolarization (Lemasters et al., 1998) than from impaired oxidativ

• br Acknowledgements This work was supported by grants from A

  2020-06-18

  

  Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras

• Cilomilast synthesis In conclusion our work provides the pre

  2020-06-18

  

  In conclusion, our work provides the preclinical evidence showing the potent in vivo efficacy of AT7519 on chemoresistant cancer Cilomilast synthesis and its underlying mechanisms of action. Our work supports the biological rationale behind the clinical trials initiated with AT7519, particularly fo

• A number of immune relevant genes

  2020-06-18

  

  A number of immune-relevant genes have been studied to explore the immunologic mechanisms in large yellow croakers; however, the chemokine receptor CXCR family has never been studied in this organism. Chemokines are a large superfamily of chemotactic cytokines that are utilized to direct the traffic

• Previous studies found that depression primarily results fro

  2020-06-18

  

  Previous studies found that depression primarily results from impaired monoaminergic neurotransmission systems [1], [2]. The glutamatergic and GABAergic systems as well as several neuropeptide systems have also been the focus of pathophysiological studies on depression [1], [2]. Inflammatory cytokin

• Injurious effects of cigarette smoke CS on

  2020-06-18

  

  Injurious effects of cigarette smoke (CS) on human health are progressively being acknowledged both in animal and human studies. CS is a highly complex mixture that contains substantive amounts of toxic oxidants, nitric oxide, organic compounds, free radicals and microbial cell components including

• br Conclusions br Statement of authorship br Nonaneurysmal s

  2020-06-18

  

  Conclusions Statement of authorship Nonaneurysmal subarachnoid hemorrhage (NA-SAH) differs from aneurysmal subarachnoid hemorrhage (SAH) in both clinical course and outcome. In spite of many reports and case series since the first description in 1985, the etiology of NA-SAH remains uncertain

• br Introduction Hematopoietic stem cells and leukemic stem c

  2020-06-18

  

  Introduction Hematopoietic stem bcr-abl inhibitors and leukemic stem cells (HSCs and LSCs, respectively) both have a capacity of self-renewal. Whereas HSCs give rise to all blood lineages during lifetime hematopoiesis, LSCs are responsible for the initiation and propagation of leukemia, as well

• The possibility of harm with DPP inhibitors in patients

  2020-06-18

  

  The possibility of harm with DPP-4 inhibitors in patients with clinically overt heart failure has been recently highlighted by the results of the VIVIDD (Vildagliptin in Ventricular Dysfunction Diabetes) trial (68), the only trial to date that has been designed to evaluate the effects of a DPP-4 inh

• br Introduction The discoidin domain receptors DDRs

  2020-06-17

  

  Introduction The discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among the receptor tyrosine kinases (RTKs) in being activated by interaction with the extracellular matrix [1], [2]. Binding to triple-helical collagen is mediated by the receptor extracellular domains that include an N

• Pathological changes in animal are

  2020-06-17

  

  Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin

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