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The current study showed that the tested nonselective COX
2019-10-24
The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti
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In the present study we determined concentration response re
2019-10-24
In the present study, we determined concentration–response relationships for selected synthetic progestogens using in vitro luciferase transactivation assays driven by PR, ARα and ARβ from Murray–Darling rainbowfish () and compared the profiles with those obtained from similar assays based on human
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Dovitinib Lactate receptor Impulsive burying and freezing be
2019-10-24
Impulsive burying and freezing behaviors in response to aversive stimuli may represent attempts to avoid novel and/or aversive stimuli. These behaviors can be assessed utilizing the marble burying and conditioned fear tasks, respectively. For example, Wistar rats in proestrus and ovariectomized rats
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br Discussion EFTs are sarcomas with
2019-10-24
Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular Vincristine mg on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immuno
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p and p which are downstream of pAkt and
2019-10-24
p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and Nitidine chloride synthesis arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It
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A major open question in the field of
2019-10-24
A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser
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The P H activity and the large number of Hyp
2019-10-23
The P4H activity and the large number of 4-Hyp residues that are formed, amounting to half of all the Pro residues or 10% of all residues, have been identified as having a clear role in the structure and chemistry of the triple helix [3]. The role of the rare 3-Hyp residues is less clear and is stil
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MNs can be obtained from iPSCs using signaling molecules
2019-10-23
MNs can be obtained from iPSCs, using signaling molecules such as retinoic AS-703026 (RA) and Sonic hedgehog (Shh) (Table S1).4, 5, 12, 23, 24, 25, 26, 27, 28, 29 These methods rely on developmental principles and require changing the combinations of signaling molecules at multiple steps, which is w
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Illumina 384 ERK and p MAPK signaling pathways play critical
2019-10-23
ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma Illumina 384 (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular signal-regulate
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Results are expressed as mean s e m Paired or
2019-10-23
Results are expressed as mean±s.e.m. Paired or unpaired Student\'s t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni\'s post-test for more groups. Statistical significance was assigned if p Results and discussion Variations in [Ca2+]i in cardiomyocytes loade
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Enolase as a plasminogen receptor
2019-10-23
Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such
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As an endogenous negative modulator CRBN inhibits AMPK
2019-10-23
As an endogenous negative modulator, CRBN inhibits AMPK’s activation (phosphorylation of Thr172) by directly binding to the α-subunit of AMPK, disrupting γ-subunit recruitment to the AMPK complex (Lee et al., 2011, Lee et al., 2013). In our study, we did not focus on AMPK activation, since only a si
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We propose two different pathways for
2019-10-23
We propose two different pathways for the production of this species: either that described by Dooley [24], where the phenol ring is first activated by binding of its oxygen to copper, or one where a copper-peroxo species would directly react with an active site tyrosine residue (Scheme 1B). This se
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Concerning family A GPCRs although it has been
2019-10-23
Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e
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Although enantioselective accumulation of metalaxyl in organ
2019-10-22
Although enantioselective accumulation of metalaxyl in organisms is an integrated outcome of bio-process including absorption, transportation, and transformation, it is observed in our study that catalysis of CYP450 may lead to the enantioselective accumulation of metalaxyl. However, the mechanisms
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