• FR 180204 Introduction Progesterone also known as P is a ste

  2019-09-04

  Introduction Progesterone, also known as P4, is a steroid hormone acting as a key component in the complex regulation of female reproductive function.

• Although the mechanisms underlying the EP mediated increase

  2019-09-03

  Although the mechanisms underlying the EP4-mediated increase in the frequency of mEPSCs via PGE2 remain unclear, mechanisms similar to those driven by EP2 may be involved because activation of both these receptor subtypes increases the intracellular concentration of cAMP (Nishigaki et al., 1995, Sugimoto and Narumiya, 2007).

• Hepatic steatosis is strongly associated with insulin resist

  2019-09-02

  Hepatic steatosis is strongly associated with insulin resistance.

• Resveratrol is a phytoalexin that occurs in relatively

  2019-08-30

  Resveratrol is a phytoalexin that occurs in relatively large amounts in peanut, berries, grapes, and red wine (Soleas et al., 2001).

• br Advent of SMEPT br SMEPT for

  2019-08-29

  Critical evaluation and outlook Examples discussed in this review present SMEPT as a methodology for localized drug synthesis – a unique opportunity for site specific therapeutic interventions using implantable biomaterials.

• The CYP A genes are

  2019-08-28

  The CYP3A genes are regulated physiologically by glucocorticosteroids, growth hormone, thyroid hormones and cytokines [13, 20, 30].

• Since ET was discovered first and showed a

  2019-08-27

  Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides.

• Distribution of DGTS in basidiomycete fungi has been

  2019-08-26

  Distribution of DGTS in basidiomycete fungi has been demonstrated to be heterogeneous.

• While a number of studies

  2019-08-24

  While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub LY2228820 specificity

• Recent studies showed that the activity

  2019-08-23

  Recent studies showed that the activity of CK2 was significantly reduced in ischemic stroke model rats, and cerebral I/R injury significantly decreased the expression of CK2α (Lee et al., 2004; Kim et al., 2012; Zhou et al., 2016).

• Because of the important role of the DDB

  2019-08-22

  Because of the important role of the DDB1-CUL4B interaction for CUL4B-based E3 ligases, disruption of the DDB1-CUL4B interaction could be an effective approach to treat cancer.

• Conventional aromatic radiofluorination via nucleophilic sub

  2019-08-21

  Conventional aromatic radiofluorination via nucleophilic substitution requires electron-withdrawing activating group(s) at the ortho or para position to achieve good radiolabeling yield.

• The detailed mechanisms of irAEs still remain elusive One of

  2019-08-20

  The detailed mechanisms of irAEs still remain elusive [13].

• How does APC C recognize its substrates and catalyze

  2019-08-19

  How does APC/C recognize its substrates and catalyze their ubiquitylation?

• br Introduction Breast cancer is

  2019-08-17

  Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1].

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