Distribution of DGTS in basidiomycete fungi has been

2019-08-26

Distribution of DGTS in basidiomycete fungi has been demonstrated to be heterogeneous.

While a number of studies

2019-08-24

While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub LY2228820 specificity

Recent studies showed that the activity

2019-08-23

Recent studies showed that the activity of CK2 was significantly reduced in ischemic stroke model rats, and cerebral I/R injury significantly decreased the expression of CK2α (Lee et al., 2004; Kim et al., 2012; Zhou et al., 2016).

Because of the important role of the DDB

2019-08-22

Because of the important role of the DDB1-CUL4B interaction for CUL4B-based E3 ligases, disruption of the DDB1-CUL4B interaction could be an effective approach to treat cancer.

Conventional aromatic radiofluorination via nucleophilic sub

2019-08-21

Conventional aromatic radiofluorination via nucleophilic substitution requires electron-withdrawing activating group(s) at the ortho or para position to achieve good radiolabeling yield.

The detailed mechanisms of irAEs still remain elusive One of

2019-08-20

The detailed mechanisms of irAEs still remain elusive [13].

How does APC C recognize its substrates and catalyze

2019-08-19

How does APC/C recognize its substrates and catalyze their ubiquitylation?

br Introduction Breast cancer is

2019-08-17

Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1].

Boc-D-FMK br Genes involved in oxysterol metabolism The main

2019-08-16

Genes involved in oxysterol metabolism The main enzymes that participate in the metabolism of oxysterols generally belong into one of two groups: transferases or oxidoreductases [22].

Although DAPK has been implicated in neuronal death in ische

2019-08-15

Although DAPK has been implicated in neuronal death in ischemic stroke and neurodegenerative diseases, such as Alzheimer’s disease (Shamloo et al., 2005, Duan et al., 2013), the mechanisms about how DAPK regulates cell death are still elusive.

Several CHK inhibitors have been

2019-08-14

Several CHK-1 inhibitors have been reported in the literature. Of these, UCN-01 (7-hydroxystaurosporine) is a potent inhibitor of CHK-1 (=5.6nM), , and has modest selectivity among other kinases. UCN-01 is currently in clinical trials.

br Significance Our understanding of the ubiquitin biology h

2019-08-13

Significance Our understanding of the ubiquitin biology has been rapidly expanding.

Hello world!

2018-07-29